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Gene Hughes (MD)   My Press Releases

CANCER AND CBD

Published on 11/30/2018
For additional information  Click Here

[A DESCRIPTION OF YOUR IMAGE HERE

CBD OIL AND CANCER: HOW IT WORKS

Not only has cannabis been shown to help fight cancer, but Cannabidiol (CBD) as well. CBD, present in CBD oil, is the non-psychoactive cannabinoid present in hemp and cannabis plants. Like THC, it works with the body’s endocannabinoid system (ECS). The ECS is a widespread regulatory system comprised of a multitude of receptors located throughout the body.

 
CBD primarily works with two receptors: CB1 and CB2. CB1 receptors are primarily located within the brain and nervous system, while CB2 receptors are primarily located within the immune system. While THC directly activates these receptors, causing psychological effects, CBD simply stimulates the body’s naturally occurring cannabinoids to activate the receptors. No High.
 
Numerous studies have shown that CBD has many powerful medicinal benefits. Initial studies have found CBD to offer the following properties:
  • Antiemetic (reduces nausea and vomiting)
  • Anti-inflammatory
  • Antioxidant
  • Antipsychotic
  • Anticonvulsant (suppresses seizure activity)
  • Anti-tumoral/anti-cancer
  • Antidepressant
  • Anxiolytic (combats anxiety)
  • Analgesic (relieves pain)

Perhaps the most well known property of CBD is its anti-cancer and anti-tumoral properties. In addition to other studies showing its ability to kill breast and lung cancer, some studies have found that CBD has the following effects:

  • Triggering cell death through apoptosis
  • Stopping malignant cells from dividing and reproducing
  • Preventing new blood vessels from growing into tumors
  • Reducing the chances of cancer cells spreading throughout the body by stopping cells from moving and invading neighboring tissues
  • Speeding up the cell autophagy, which is the internal waste disposal mechanism
This preliminary research, is incredibly promising...
 
There Are 4 Ways Cannabis Kills Cancer 
While it may be difficult to believe, cannabis kills cancer cells. A wealth of recent research has found that cannabinoids, the active compounds in cannabis, prevent cancer from spreading, growing, and even cause tumor cells to die.
 

1. Anti-proliferative

One issue with cancer cells is that they don’t stop growing. Once a malignant tumor begins, cancer cells continue to divide and conquer. New cancer cells are continuously being made. The cells then rapidly spread to other tissues in the body. This process of growing and spreading is proliferation.

Here’s how CBD can help: the active compounds in the herb are anti-proliferative. A 2014 review published in Oncotarget found that cannabinoids inhibited cell proliferation in breast, prostate, and lung cancers. These anti-proliferative effects are thought to apply to other cancers and medical conditions as well.

A year earlier, in 2013, a team of Italian scientists found that non-psychoactive CBD protected against cancer cell “migration, adhesion, and invasion”.

Back in 2010, researchers found that cannabis also had an anti-proliferative effect in deep infiltrating endometriosis, where painful lesions appear on various female reproductive organs. Endometriosis increases your risk of developing cancer.

2. Anti-metastatic

When cancer cells migrate from part of the body to another, the cells become metastatic. Cancer cells break away from the original tumor, travel through the blood or lymph system, and make a home elsewhere in the body. This is why some people with breast cancer later develop cancers of the bone, liver, brain, or lungs.

Recent research discovered that cannabinoids block metastasis. Over the past two decades, Spanish scientists at the Complutense University of Madrid have been studying the impact of cannabinoids and cancer cells.

In 2012, they found that compounds in the herb had anti-metastatic effects in tumor cells. In a recent review, lead author Guillermo Velasco cited over 12 studies evidencing cannabinoid protection against metastatic cancers.

3. Anti-angiogenesis 

For tumors to survive, they need blood. Unfortunately, they take all of the blood they need through a process called angiogenesis. Angiogenesis enables tumors to grow blood vessels. This helps them grow larger and larger over time until they impede normal bodily functions.

Researchers have been trying to develop drugs which stop tumors from creating blood cells. Fortunately, cannabinoids seem to do just that.

In 2008, a Spanish research team led by Cristina Blázquez discovered that psychoactive THC weakens a tumor’s ability to develop new blood vessels. While the team looked at brain cancer cells called gliomas specifically, they mention that the same effects have been found in melanomas and skin carcinomas as well.

Additional research from 2011 from Vanderbilt University cited evidence that non-psychoactive CBD is also anti-angiogenic, though it works differently from THC. This is big news, as it shows that the active compounds in cannabis fight tumor cells in a variety of ways.

4. Apoptosis

Already, cannabinoids stop tumor cells from spreading, slow down growth, and cut off their blood supply. But, can cannabis actually kill cancer cells? Research suggests that it can.

A recent study published in Current Oncology  found that both THC and CBD were effective in killing neuroblastoma cells. Neuroblastomas are the most common tumors among children. With this particular type of cancer, CBD was more effective.

But, how is this possible? Simply said, CBD caused the brain tumor cells to commit suicide. The technical name for cell suicide is apoptosis. Apoptosis is a natural mechanism that your body uses to clear out cells that are damaged and ineffective.

This phenomenon is known as “Programmed Cell Death” and it helps maintain the health of your cells. For some reason, cancer cells no longer die. They evade apoptosis. Research as early as 1998 has found that cannabinoids trigger apoptosis in tumor cells, meaning they actually die.

All of the above research has profound implications on the future of cancer treatment. Currently, chemotherapy and radiation are the go-to methods for cancer management, but the treatments are taxing and have long-term side effects.

According to Dr. Peter Glidden 97 Percent of the time, chemotherapy does not work, and is a waste of money! 

"To an industry that does not even know how to cure heart burn, we have given 600 BILLION dollars to come up with a cure for cancer. Gee, I wonder why we aren't any closer to a cure since Richard Nixon declared a war on cancer (44yrs ago)." - Dr. Peter Glidden

Research and Case Studies on the effects of Cannabis to treat Cancer 

( to access the actual studies listed below Click Here )

General

  • CBD as potential anticancer drug
  • CBD inhibits angiogenesis by multiple mechanisms
  • The inhibitory effects of CBD on systemic malignant tumors
  • CBD inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1
  • Marijuana fights cancer and helps manage side effects
  • In vitro and in vivo efficacy of non-psychoactive cannabidiol in neuroblastoma
  • The Influence of Biomechanical Properties and Cannabinoids on Tumor Invasion
  • Antitumorigenic targets of cannabinoids – current status and implications
  • Cannabinoids – a new weapon against cancer?

Bladder Cancer

  • TRPV2 activation induces apoptotic cell death in human T24 bladder cancer cells: a potential therapeutic target for bladder cancer

Brain Cancer

  • Cannabidiol enhances the inhibitory effects of delta9-THC on human glioblastoma cell proliferation and survival
  • Antitumor effects of CBD, a nonpsychoactive cannabinoid, on human glioma cell lines
  • Systematic review of the literature on clinical and experimental trials on the antitumor effects of cannabinoids in gliomas
  • CBD inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism
  • Id-1 is a key transcriptional regulator of glioblastoma aggressiveness and a novel therapeutic target
  • Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents
  • CBD inhibits proliferation and invasion in U87-MG and T98G glioma cells through a multitarget effect
  • Local delivery of cannabinoid-loaded microparticles inhibits tumor growth in a murine xenograft model of glioblastoma multiforme
  • Synergistic responses between cannabidiol and DNA-damaging agents on the proliferation and viability of glioblastoma and neural progenitor cells in culture
  • Cannabis improved survival of patients with aggressive brain cancer in controlled clinical study

Breast Cancer

  • Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma
  • CBD induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy
  • Pathways mediating the effects of CBD on the reduction of breast cancer cell proliferation, invasion, and metastasis
  • CBD as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells
  • Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration
  • CBD-A mediated selective down-regulation of c-fos in highly aggressive breast cancer MDA-MB-231 cells

Colon Cancer

  • Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer
  • Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of CBD
  • Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent

Endocrine Cancer

  • Endocannabinoids in endocrine and related tumours
  • A comparative study on CBD-induced apoptosis in murine thymocytes and EL-4 thymoma cells

Kaposi Sarcoma

  • CBD inhibits growth and induces programmed cell death in kaposi sarcoma-associated herpes virus-infected endothelium

Leukemia

  • CBD-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression
  • CBD-Induced Apoptosis in Human Leukemia Cells
  • Cannabidiol Reduces Leukemic Cell Size 

Lung Cancer

  • CBD inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1C
  • COX-2 and PPAR-γ confer cannabidiol-induced apoptosis of human lung cancer cells
  • Decrease of plasminogen activator inhibitor-1 may contribute to the anti-invasive action of CBD on human lung cancer cells
  • Media ignored expert’s shocking findings that marijuana helps prevent lung cancer

Pain

  • Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain
  • Nabiximols for opioid-treated cancer patients with poorly-controlled chronic pain: a randomized, placebo-controlled, graded-dose trial
  • Marijuana extract helps prevent chemo pain

Pancreatic Cancer

  • Cannabinoid derivatives induce cell death in pancreatic MIA PaCa-2 cells via a receptor-independent mechanism.
  • Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes.
  • The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells.

Prostate Cancer

  • Towards the use of non-psychoactive cannabinoids for prostate cancer
  • In Vitro Anticancer Activity of Plant-Derived Cannabidiol on Prostate Cancer Cell Lines
  • Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent

Skin Cancer

  • Anticancer activity of anandamide in human cutaneous melanoma cells

In conclusion, instead of accepting cannabinoids as a cure for all cancers, the better approach is understanding that these compounds have shown a lot of potential to combat some types of tumors. Therefore, in case you want to try some full spectrum CBD oil or THC extracts to treat some form of cancer, do it only as a supplement to the treatment recommended by your oncologist.

So, is CBD good for cancer patients? The answer is – absolutely YES! This is because besides its anticancer properties, CBD has many other medicinal properties including: reducing inflammation, pain, seizures, vomiting, and muscle spasms as well as promoting appetite, bone growth and protecting the cells in the nervous system.

Every day, new evidence is trickling in, especially from animal studies, helping researchers to understand how CBD works to effect cancer, tumor growth and cancer-related symptoms. 

The potential of CBD to treat various forms of Cancer continues to be supported by an ever-growing body of research. 

Wait For It.......Wait For It.......Wait...

The Food and Drug Administration (FDA) clearly thinks that cannabis’ cancer-curing properties is fake news.

The FDA sent a message to companies who manufacture and sell cannabis products claiming that it can “prevent, diagnose, treat, or cure cancer”. Four companies (and I'm sure, and counting) were targets of the agency’s efforts in trying to suppress the fact that cannabis CAN cure cancer, because they claimed that their CBD products can help stop cancer from spreading.

These warnings are part of the FDA’s latest campaign in an attempt to stop “healthcare fraud”

According to FDA Commissioner Dr. Scott Gottlieb, “Substances that contain components of marijuana will be treated like any other products that make unproven claims to shrink cancer tumors. We don’t let companies market products that deliberately prey on sick people with baseless claims that their substance can shrink or cure cancer and we’re not going to look the other way on enforcing these principles when it comes to marijuana-containing products.”

The FDA also points out that the cancer-curing claims aren’t supported by any evidence. It’s illegal to sell products that have unapproved and unsubstantiated therapeutic claims, as this goes against the Federal Food, Drug, and Cosmetic Act.

“We support sound, scientifically based research using components derived from marijuana, and we’ll continue to work with product developers who are interested in bringing safe, effective, and quality products to market,”

Cannabidiol (CBD), is one of the compounds of the cannabis plant which has been linked to several dozen studies (not including the anecdotal evidence) proving its efficacy in curing cancer by changing how the body treats the cancer cells; in some cases CBD induces aptosis in cancer cells (cancer cell suicide), while in other cases it prevents tumors from spreading at all.

But according to the FDA, CBD is undergoing “substantial clinical investigation” as feasible cancer treatment.

In the FDA’s statement, the agency published product claims that were used by the companies. These included “CBD combats tumor and cancer cells”, “CBD makes cancer cells commit ‘suicide’ without killing other cells,’ “CBD..[has] antiproliferative properties that inhibit cell division and growth in certain types of cancer, not allowing the tumor to grow,” and “Nonpsychoactive cannabinoids like CBD may be effective in treating tumors from cancer – including breast cancer.”

Despite what we know and what science says about CBD and its effect on cancer, the FDA thinks that companies should stay away from marketing these claims to sell their products. The FDA is also wary not just about the fact that these claims are baseless, but the fact that these products are taking patients away from other legitimate treatments (hint: Big Pharma).

“When people are allowed to illegally market agents that deliver no established benefit, they may steer patients away from products that have no proven, antitumor effects that could extend lives,” says Gottlieb, a cancer survivor himself who was successfully treated for Hodgkin’s lymphoma.

The FDA also used the safety card, albeit unfairly: they claim that these cannabis products weren’t subject to FDA review, unlike other drugs that have been approved by the agency which is why they say that they have no idea about how they work, if they work at all, any side effects, dosage information, and other safety concerns. The FDA has also asked these companies to provide responses on how they intend to correct these violations; the failure to do so may end up in legal action, possibly product seizure.

“We have an obligation to provide caregivers and patients with the confidence that drugs making cancer treatment claims have been carefully evaluated for safety, efficacy, and quality, and are monitored by the FDA once they’re on the market,” said Gottlieb.

“We recognize that there’s interest in developing therapies from marijuana and its components, but the safest way for this to occur is through the drug approval process – not through unsubstantiated claims made on a website.”

According to Gottlieb, there are no cannabis-derived products that have been approved by the FDA. He conveniently fails to mention how others are already in later-stage clinical trials, such as GW Pharmaceuticals’ epilepsy treatment, or Zynerba Pharmaceuticals’ cannabis gel for autism.

Seems like the FDA needs cannabis to help them treat their selective memory.

[A DESCRIPTION OF YOUR IMAGE HERE

 

[A DESCRIPTION OF YOUR IMAGE HERE

[A DESCRIPTION OF YOUR IMAGE HERE

 

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