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Chuck Reynolds
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What does Resveratrol induce.? P-9, P-3

Published on 6/20/2019
For additional information  Click Here

Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition P-9


Resveratrol was reported to directly inhibit various enzymes as demonstrated by in vitro activity assays. Among these enzymes, PI3K and PKC showed ATP-dependent inhibition by resveratrol. However, the studies provided no evidence for the link between the inhibition of these molecules and the beneficial effects of resveratrol administration. Further studies are needed to determine the position of physiological targets of resveratrol. In addition to kinases, PDE, which uses cAMP as a substrate, is also inhibited by resveratrol in a substrate-competitive manner.

Notably, mTOR had the lowest IC50 value for resveratrol compared to PI3K, PKC, and PDE. Resveratrol, ATP, and cAMP are similar in structure, which suggested that resveratrol could compete with cAMP or ATP for single binding sites. Additionally, PP242 and quercetin, an mTOR kinase inhibitor and a natural polyphenol, respectively, are similar in structure.

We found that resveratrol showed a cancer-cell-type-selective effect on viability in that it suppressed only the viability of MC7 cells, but not that of SW620 cells. However, we could not find any differences in the level of apoptosis between MCF7 and SW620 cells, which may indicate the involvement of other cellular processes. Notably, Colin et al. suggested acquired resistance to resveratrol in SW620 cells, which is dependent on the DNA-damage response39. Therefore, it remains to be determined whether mTOR and the DNA-damage response are associated with the determination of resveratrol resistance in SW620 cells.

Article Produced By

Department of Life Sciences, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea
School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea
School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan 689-798, Republic of Korea
Department of Bioscience and Biotechnology, Sejong University, 98 Kunja-Dong, Kwangjin-Ku, Seoul 143-747, Republic of Korea

(All these Articles can be read with this URL: )

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Chuck Reynolds

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